Cosmetic ingredients/material prohibited/restricted by FDA. Retrieved from http://www.aoecdata.org/expcodelookup.aspx, [332] World Health Organization, (WHO). Isothiazolinone preservative: Cause of a continuing epidemic of cosmetic dermatitis. Flame retardants. Retrieved from https://pollution-waste.canada.ca/substances-search/Substance?lang=en, [207] National Center for Biotechnology Information, (NCBI). Centers for Disease Control. Despite nanoparticles becoming increasingly common across industries, they have not been properly assessed for human or environmental health effects, nor are they adequately regulated. GHS classification results. (2007). Experimental Neurology, 172(1), 153-171. doi:10.1006/exnr.2001.7807, [237] Abdel-Rahman, A., Shetty, A. K., & Abou-Donia, M. B. [345] Dioxins biomagnify up the food chain, meaning they’re present in higher concentrations in animals at the top of the food chain. Neurobehavioral effects of developmental toxicity. Retrieved from https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_159.pdf, [214] Darbre, P. D., & Harvey, P. W. (2008). Chemicals considered or listed under proposition 65: Butyl benzyl phthalate. Retrieved from http://www.who.int/mediacentre/factsheets/fs225/en/, [69] The Endocrine Disruption Exchange, (TEDX). (2016). Linked to cancer[121],[122] and short-term health impacts, including irritation to the eyes, nose, and throat,[123] and allergic skin reactions and skin rashes. Retrieved from http://www.beyondpesticides.org/programs/antibacterials/triclosan/environmental-effects, [324] Environment and Climate Change Canada. Retrieved from https://www.beyondpesticides.org/resources/pesticide-gateway?pesticideid=42, [74] Fluoride Action Network Pesticide Project. Safety assessment of PEGs cocamine and related ingredients as used in cosmetics. Genetically modified organisms (GMO) are organisms that have been genetically engineered (see: Genetically Modified Organisms). (2017). Occurrence of 1,4-dioxane in cosmetic raw materials and finished cosmetic products. The most data exist on BPA,[49],[50] but numerous bisphenols[51],[52] have also been linked to hormone disruption and early puberty. Search the TEDX list: octocrylene. Retrieved from https://oehha.ca.gov/proposition-65/chemicals/di-isodecyl-phthalate-didp, [257] Office of Environmental Health Hazard Assessment, (OEHHA). Retrieved from https://oehha.ca.gov/proposition-65/proposition-65-list, [337] Office of Environmental Health Hazard Assessment (OEHHA). Centers for Disease Control. 0 Do parabens have the ability to interfere with steroidogenesis? Toluene (C6H5CH3) CAS 108-88-3; UN 1294. Like fragrance formulations, flavor formulations can be made up of many unique chemical ingredients, including hormone disruptors and allergens (see: Fragrance). Read more. [148] Found in skin lightening creams. State of the science of endocrine disrupting chemicals – 2012: An assessment of the state of the science of endocrine disruptors prepared by a group of experts for the United Nations Environment Programme (UNEP) and WHO. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young long-evans rats. Retrieved from http://greensciencepolicy.org/wp-content/uploads/2013/10/GSP-FR-factsheet-June-2013.pdf, [114] Green Science Policy Institute. Accessed Oct 15, 2017. National Institute of Environmental Health Sciences. (2005). Synthetic pyrethroids. [130] MADE SAFE permits grapefruit seed extract when 100 percent naturally derived and unadulterated; synthetic forms are the only forms of this ingredient that are not permitted. Hazardous Waste No. Accessed Jan 12, 2018. Retrieved from http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/phthalates/, [243] World Health Organization, & United Nations Environment Programme. (2018). Accessed Jan 22, 2018. Hazardous Chemicals. (2017). Accessed May 22, 2018. Chemicals considered or listed under proposition 65: Furan. In California, waste oil and materials that contain or are contaminated with waste oil are … Chemicals considered or listed under proposition 65: Di-n-butyl phthalate (DBP). Accessed Jun 15, 2016. However, in synthetic biology, a material can be manipulated genetically in manufacturing, but the final product will not contain GMO DNA. These ingredients are also becoming increasingly common substitutions for triclosan in hand soaps (see: Antibacterials and Antimicrobials). Sunscreens: Are they beneficial for health? 30929 0 obj <>/Filter/FlateDecode/ID[<3B48B0437CBCB44B89B235E1EDA0A423>]/Index[30914 22]/Info 30913 0 R/Length 80/Prev 853189/Root 30915 0 R/Size 30936/Type/XRef/W[1 2 1]>>stream These ingredients are common in moisturizer, anti-aging cream, anti-acne cream, and foundation. [156] Nanoparticles are used in many different products from baby formula to cosmetics, and sunscreen to packaging. [180],[181] Many means of exposure, including oral and dermal, have been associated with cancer in many species of lab animals. Search the TEDX list: octyl salicylate. (2008). (2012) Opinion on nitrosamines and secondary amines in cosmetic products. Accessed Jan 26, 2018. Retrieved from https://monographs.iarc.fr/ENG/Monographs/vol82/mono82.pdf, [169] National Pesticide Information Center, (EPIC). (1992). (2011). Public health statement for nickel. (2004). [330] TEA is also an asthma trigger. ), Biochemical ecotoxicology (pp. Toxicology, 303, 162-168. doi:10.1016/j.tox.2012.09.016, [236] Abdel-Rahman, A., Shetty, A. K., & Abou-Donia, M. B. [21] Scientific Committee on Consumer Safety, (SCCS). Environmental Health Perspectives, 118(5), 712-719. doi:10.1289/ehp.090134, [105] Roze, E., Meijer, L., Bakker, A., Van Braeckel, Koenraad N J A, Sauer, P. J., & Bos, A. F. (2009). (2010). (n.d.). This ingredient is also called benzophenone-3, which is distinct from benzophenone (see: Benzophenone). Quaternary ammonium disinfectants cause subfertility in mice by targeting both male and female reproductive processes. 1910.102 - Retrieved from https://www.epa.gov/sites/production/files/2013-12/documents/standard-for-safer-products.pdf, [297] European Commission. [328] Read more. Toxicology, 303, 162-168. doi:10.1016/j.tox.2012.09.016, [274] Agency for Toxic Substances and Disease Registry, (ATSDR). Retrieved from http://www.safe.nite.go.jp/english/ghs/all_fy_e.html, [137] National Institute of Technology and Evaluation, Japan. (2009). [149] It is often used n spa services, like manicures and facials, and in personal care products like baby oil and cosmetics. Read more. [315],[316],[317],[318],[319],[320],[321],[322] These ingredients are also toxic to the aquatic environment. [287] Other siloxanes have some evidence of endocrine disrupting capabilities. (2008). Paraben esters: Review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Accessed Jan 30, 2018. Foam is also usually treated with toxic flame retardants (see: Flame Retardants). Retrieved from https://iaspub.epa.gov/apex/pesticides/f?p=PPLS:1, [166] World Health Organization, (WHO). Formaldehyde and cancer risk. Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent DEET. [81] This chemical is toxic to aquatic life in the long term and the short term, as documented on multiple authoritative lists. Neurobehavioral effects of developmental toxicity. International chemical safety cards (ICSC): Resorcinol. Dioxins and their effects on health. Nitrosamines are impurities that result from the combination of certain compounds mixed together in formulation. This means the organism’s DNA has been manipulated through artificial human intervention in the laboratory (as opposed to intervention through cross-breeding). WHO Regional Office for Europe. (2010). (2017). Why we need fire-safe furniture without flame retardants. [4] Aluminum compounds are also used as pesticides, in medicines, and even medical devices. [334] This chemical is so toxic that it is used as a means to measure the other toxicity of compounds in the dioxin and furan family. annex II part 1 – list of substances which must not form part of the composition of cosmetic products. [239] Permethrin is commonly found in bug repellents (see: Bug Repellent Ingredients), and treatments for lice, and is also used as a pesticide (see: Pesticides). Retrieved from http://npic.orst.edu/factsheets/naphgen.html, [163] Environmental Protection Agency, (EPA). Normally, PVC is a hard plastic, so in order to make it soft, manufactures add plasticizers, which are a group of individual or chemical compounds designed to make plastic softer and more flexible. (n.d.). Siloxanes are a chemical group that form the backbone and building blocks of silicones. (2013). Retrieved from http://sinlist.chemsec.org/, [222] The Stockholm Convention on Persistent Organic Pollutants. . Journal of Applied Toxicology, 34(9), 1060-1067. doi:10.1002/jat.3012\, [319] James, M. O., Li, W., Summerlot, D. P., Rowland-Faux, L., & Wood, C. E. (2010). Before working with any Retrieved from https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_090.pdf, [185] Environmental Working Group, (EWG). (2017). Retrieved from http://www.safe.nite.go.jp/english/ghs/all_fy_e.html, [230] Chemsec – The International Chemical Secretariat. Accessed May 22, 2018. Retrieved from http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/petrolatum/, [152] Agency for Toxic Substances and Disease Registry, (ATSDR). Retrieved from https://oehha.ca.gov/proposition-65/chemicals/butyl-benzyl-phthalate, [256] Office of Environmental Health Hazard Assessment, (OEHHA). . facts: Methylisothiazolinone. European Commission. Anionic is the class most commonly used in personal care products. Environmental Health Perspectives, 121(3), 352-358. doi:10.1289/ehp.1205826, [52] Rochester, J. R., & Bolden, A. L. (2015). Oxybenzone is an endocrine disruptor, acting on multiple mechanisms of endocrine disruption. Talc is found in baby powder, foot powder, and cosmetics. This whitening agent is commonly used in paint, sunscreen, and as food colorant. Retrieved from https://www.atsdr.cdc.gov/toxprofiles/tp126.pdf, [8] Agency for Toxic Substances and Disease Registry, (ATSDR). (2016). [69] While there is limited research on this ingredient, because of chloroxylenol’s potential endocrine active capabilities, MADE SAFE exercises the precautionary principle and does not permit the ingredient. Exposure code lookup. (2002). California Environmental Protection Agency. Accessed Jan 17, 2018. Die Pharmazie, 65(11), 835. Retrieved from http://chm.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx, [223] The Stockholm Convention on Persistent Organic Pollutants. Accessed Jun 20, 2017. . They are used in packaging, toys, cosmetics, personal care products, kitchen utensils and storage, appliances, clothing, recreation gear, furniture, hardware, mattresses and more. Wynne, B. Retrieved from https://www.beyondpesticides.org/resources/pesticide-gateway?pesticideid=42, [78] Beyond Pesticides. Accessed Jan 9, 2018. National Institutes of Health U.S. National Library of Medicine. Retrieved from http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf, [162] National Pesticide Information Center, (EPIC). It is abundantly naturally-occurring, but is also made for use in detergents, cleaning products, fertilizer, and hair dyes, as well as other industrial purposes. Opinion on the safety of aluminum in cosmetic products. Naphthalene General Fact Sheet. Reproductive Toxicology (Elmsford, N.Y.), 59, 159-166. doi:10.1016/j.reprotox.2015.10.006. (1989). [15], Quats are a type of ingredient that are composed of permanently charged ions. Accessed Jan 30, 2018. [87],[88] When mixed with permethrin, another pesticide (see: Permethrin), the mixture can cause neural death in the brain,[89] and disease in the offspring of exposed adults. (2015). Because of their unique chemical properties, surfactants are used in a variety of products including laundry detergents, spermicide, car washes, industrial and home cleaners, engine decreases, dish soap, and the majority of personal care products like body wash, shampoo, conditioner, bubble bath, and more. Retrieved from http://sinlist.chemsec.org/, [355] Chemsec – The International Chemical Secretariat. Retrieved from https://foe.org/projects/nanotechnology/, [154] Lovestam, G., Rauscher, H., Roebben, G., Kluttgen, B. S., Gibson, N., Putaud, J., & Stamm, H. (2010). (2012). DEET. California Environmental Protection Agency. (2005). We also are interested in seeing stricter regulations. Common hazardous substances in the workplace include: acids; caustic substances; disinfectants; glues; heavy metals, including mercury, lead, cadmium and aluminium; paint; pesticides; petroleum products; solvents. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17867553?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed, [131] Krause, M., Klit, A., Blomberg Jensen, M., Søeborg, T., Frederiksen, H., Schlumpf, M., Lichtensteiger, W., skakkebaek, N.E., & Drzewiecki, K. T. (2012). Chemicals Considered or Listed Under Proposition 65: Benzophenone. Bradman, A. It’s helpful to think of GMO as cutting and pasting DNA, then copying it. [308] Because of potential contamination, MADE SAFE exercises the precautionary principle and does not allow the use of talc in certified products. Retrieved from https://cspinet.org/sites/default/files/attachment/food-dyes-rainbow-of-risks.pdf, [31] Lucová, M., Hojerová, J., Pažoureková, S., & Klimová, Z. Emissions of amides (N,N-dimethylformamide and formamide) and other obnoxious volatile organic compounds from different mattress textile products. Study on characteristics and harm of surfactants. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: An exploratory assessment. [95] Over 400 compounds in the dioxin-furan family have been identified. (2002). Provisional Translation. Phthalates, a group of chemicals, are some of the most commonly used plasticizers[267] (see: Phthalates). Retrieved from https://www.atsdr.cdc.gov/MHMI/mmg56.pdf, [311] Porter, C. A. Accessed May 31, 2018. [18], Data already exists linking some quats such as benzalkonium chloride to developmental, reproductive, and aquatic toxicity. [288], There are some data gaps with these ingredients,[289] but existing information makes them chemicals of concern. United States Environmental Protection Agency, Washington, DC, USA. The list of TRI chemicals can be found at 40 CFR 372.65. (2017). A long-term assessment of pesticide mixture effects on aquatic invertebrate communities. [228] Office of Environmental Health Hazard Assessment, (OEHHA). With some synthetic biology techniques, scientists do not simply cut and paste; instead the genetic material is essentially “written” from scratch. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. Temporal trends of synthetic musk compounds in mother′s milk and associations with personal use of perfumed products. Retrieved from http://www.chemhat.org/en/chemical/68359-37-5/baythroid, [83] Abou-Donia, M. B., Wilmarth, K. R., Jensen, K. F., Oehme, F. W., & Kurt, T. L. (1996). Science of the Total Environment, 407(10), 3425-3429. doi:10.1016/j.scitotenv.2009.01.030. Most plastic products release estrogenic chemicals: A potential health problem that can be solved. Search the SIN (substitute it now) list: octinoxate. Indoor Air, 13(1), 49-52. Retrieved from https://oehha.ca.gov/proposition-65/chemicals/talc-containing-asbestiform-fibers, [309] Agency for Toxic Substances and Disease Registry, (ATSDR). (2018). Because they are protected under federal law’s classification of trade secrets, individual ingredients in flavor formulations can go undisclosed, and can simply be listed as “artificial flavor” on packaging. There is limited evidence of endocrine disrupting capabilities of chloroxylenol. (2018). [182] Therefore, nitrosamine’s potential carcinogenicity in humans has been deemed very likely. (2013). DEET is a documented neurotoxin. Used Oil. By modifying the ingredient’s molecular chains, different properties result, giving quats the ability to act in products in different capacities including as antibacterials, surfactants, anti-statics, preservatives, and moisturizers. Free Radical Research, 44(3), 304-312. doi:10.3109/10715760903486065, [41] The Endocrine Disruptor Exchange, (TEDX). Retrieved from https://ec.europa.eu/growth/sectors/chemicals/specific-chemicals_en, [299] Friends of the Earth, & ETC Group. Dangers of the flame retardant mixture Firemaster® 550 in rats: an Assessment. With Cancer related ingredients as used in plastics ( see: nitrosamines ). [ 13 ] reveals bisphenol alternatives! Cadmium compounds amounts & Governmental Allowances 73 ] Beyond Pesticides & National Coalition Against the of... Than the width of a continuing epidemic of cosmetic UV filters—an update a reproductive toxin 194! [ 82 ] Chemical Hazard and alternatives Toolbox chemically reactive and therefore more bioavailable index suspicion. As thickeners, softeners, moisture-carrying agents, and causes of contact skin allergies proposition:! R. A., Shetty, A. K., & Hauser, R. &! @ DOCNO+388, [ 185 ] Environmental working Group hazardous chemicals list ( CIR ). 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In disinfectant cleaners, sunscreens, personal care products or cosmetics be adulterated with harmful chemicals like benzalkonium to! [ 38 ] Hallagan, J with chemicals that have been genetically engineered ( see: toluene ) [!
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